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Target intelligence / Profile preview
Proteinase-Activated Receptor 2 (PAR2)
- Target
- PAR2
- Molecular classification
- G protein-coupled receptor, Protease-activated receptor family, GPCR
01
Overview
Proteinase-Activated Receptor 2 (PAR2) is a G protein-coupled receptor activated by proteolytic cleavage. Activation occurs through serine proteases like trypsin, exposing a tethered ligand that binds intramolecularly to activate the receptor. PAR2 is widely expressed and plays a role in inflammation, immune response, skin homeostasis, metabolism, cancer, and various inflammatory diseases. Signal termination occurs through internalization and lysosomal degradation.
- Other names
- Protease-activated receptor 2Coagulation factor II (thrombin) receptor-like 1F2RL1G-protein coupled receptor 11GPR11
02
Mechanism of action
N/A
03
Biological functions
Signal transductionInflammation modulationImmune response regulationSkin homeostasisMetabolic process modulation
04
Disease associations
InflammationSkin diseasesMetabolic disorders/ObesityCancerAsthma/Lung injuryInflammatory bowel diseaseIrritable bowel syndromeArthritis/Joint painPancreatitis
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