Proteins and DNA

The term 'Proteins and DNA' refers to two fundamental and distinct classes of biological macromolecules rather than a single, discrete therapeutic target. Proteins are polymers of amino acids that perform a vast array of functions, including acting as enzymes, receptors, and structural components within the cell (Alberts et al., Molecular Biology of the Cell, 2002). DNA, or deoxyribonucleic acid, is the molecule that carries the genetic instructions for the development, functioning, and reproduction of all known organisms (Watson & Crick, Nature, 1953). In the context of pharmacology, proteins represent the largest class of drug targets, with specific examples including G protein-coupled receptors and kinases. DNA is also a target for various therapeutic agents, such as intercalating agents and alkylating drugs used in oncology to disrupt replication (NIH, National Cancer Institute). However, grouping these two massive categories together does not provide the specificity required for drug discovery or clinical application. Consequently, this entry is considered too broad and non-specific to be classified as a single therapeutic target.

Other names

MacromoleculesBiopolymers

Not applicable for a broad macromolecular category.