Proteins associated with cancer development

"Proteins associated with cancer development" is an umbrella term referring to a diverse collection of molecular entities involved in tumor initiation, progression, and immune evasion. The Checkpoint Therapeutic Target Database (CKTTD) alone catalogs 105 checkpoint protein targets involved in cancer immunotherapy, while proteogenomic analyses have identified over 2,800 potential therapeutic targets across 10 cancer types. These proteins span multiple functional categories including immune checkpoint molecules, cell cycle regulators, signaling pathway components, and proteins involved in DNA repair. The category includes well-known targets like programmed cell death protein 1 (PD-1), programmed death-ligand 1 (PD-L1), and KRAS, as well as hundreds of less-characterized proteins identified through pan-cancer proteogenomic profiling. This is not a single therapeutic target but rather represents the entire landscape of protein-based drug discovery opportunities in oncology, with targets classified into different tiers based on their druggability and clinical relevance.

Other names

Cancer-associated proteinsOncoproteinsTumor-associated proteinsCancer development proteinsCheckpoint targetsImmune checkpoint proteins

Inhibition of checkpoint proteins; Blockade of immune suppression; Inhibition of kinase activity; Modulation of protein-protein interactions; Targeting overexpressed or hyperactivated proteins; Immune system activation through neoantigen targeting