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Target intelligence / Profile preview
Proteoglycan 4 (PRG4)
- Target
- PRG4
- Molecular classification
- Glycoprotein, Proteoglycan
01
Overview
Proteoglycan 4 (PRG4), also known as lubricin, is a mucinous glycoprotein primarily recognized for its role as a boundary lubricant in articulating joints. It protects cartilage, modulates inflammation via TLRs, and binds neutrophils via L-selectin. Mutations or deficiencies in PRG4 are associated with joint abnormalities and arthropathies, making it a target for therapeutic intervention using recombinant forms to restore normal lubrication dynamics and anti-inflammatory properties.
- Other names
- LubricinSuperficial Zone Protein (SZP)Megakaryocyte-Stimulating Factor (MSF)CACPHAPOJCAPMSFSZPbG174L6.2
02
Mechanism of action
Recombinant PRG4 can inhibit NF‑κB signaling pathways and modulate TLR2 and TLR4 signaling.
03
Biological functions
Joint lubricationCartilage protectionImmunomodulationInflammation controlCell adhesion inhibition
04
Disease associations
Camptodactyly-Arthropathy-Coxa Vara–Pericarditis SyndromeArthropathiesOsteoarthritisInflammation
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