Proteoglycan-modified stromal receptor

The Proteoglycan-modified stromal receptor is a key regulatory protein complex found on the surface of metastatic cancer-associated fibroblasts (mCAFs). It plays a pivotal role in the tumor microenvironment by integrating signals that promote extracellular matrix remodeling, epithelial-mesenchymal transition, and immune suppression, all of which facilitate the spread of cancer cells. The receptor is characterized by its specific proteoglycan modifications, which are necessary for its pro-metastatic activity. The small molecule Akos is a first-in-class inhibitor designed to selectively target this receptor, effectively reprogramming the stroma to halt the metastatic cascade. Preclinical studies have demonstrated that blocking this receptor can significantly reduce tumor growth and completely prevent the formation of metastatic foci across various solid tumor types.

Other names

Proteoglycan-modified receptor in mCAFMetastatic CAF proteoglycan receptormCAF-specific proteoglycan receptor