Proteoglycan synthesis and secretion in endothelial cells

Proteoglycan synthesis and secretion in endothelial cells is a complex biological process responsible for the production of the endothelial glycocalyx and the vascular extracellular matrix (Source: PubMed 17604508). This process involves the transcription of core proteins, such as syndecans, perlecan, and versican, and the subsequent enzymatic addition of glycosaminoglycan (GAG) chains in the Golgi apparatus (Source: PubMed 1908458). These proteoglycans are critical for maintaining the vascular permeability barrier, regulating inflammation by modulating leukocyte adhesion, and sequestering growth factors (Source: PubMed 23603541). In pathological states like atherosclerosis and diabetes, the synthesis and secretion of these molecules are altered, leading to increased lipid retention and vascular wall thickening (Source: PubMed 15142754). While not a single molecular target, this pathway is modulated by various drugs, including statins and endothelin receptor antagonists, which can alter the composition and quantity of secreted proteoglycans to improve vascular function (Source: PubMed 11566922, 25349199). Understanding the regulation of this process is crucial for developing therapies aimed at restoring the endothelial glycocalyx and preventing cardiovascular complications.

Other names

Endothelial proteoglycan metabolismGlycocalyx assemblyProteoglycan biosynthesisEndothelial glycocalyx synthesis

Modulation of the expression and activity of enzymes involved in glycosaminoglycan chain assembly and core protein synthesis (Source: PubMed 11566922).