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Target intelligence / Profile preview
Proteolipid Protein (PLP)
- Target
- PLP
- Molecular classification
- Integral membrane protein, Proteolipid
01
Overview
Proteolipid protein (PLP), also known as myelin proteolipid protein or lipophilin, is the major integral membrane protein of central nervous system (CNS) myelin. It is highly hydrophobic and plays a critical role in the formation, compaction, stabilization, and maintenance of the multilamellar structure of myelin sheaths that insulate axons and facilitate rapid nerve impulse conduction. Mutations or abnormal expression/splicing cause several neurological disorders.
- Other names
- Myelin proteolipid proteinLipophilinPLP1
02
Biological functions
MyelinationOligodendrocyte developmentAxonal survivalRegulation of oligodendrocyte progenitor cell migrationMaintenance of CNS myelin sheathStabilization of CNS myelin sheathCompaction of CNS myelin sheath
03
Disease associations
Pelizaeus–Merzbacher diseaseSpastic paraplegia type 2Demyelinating diseases
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