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Proteolipid Protein 1 (PLP1)
- Target
- PLP1
- Molecular classification
- Structural protein, Transmembrane protein
01
Overview
Proteolipid protein 1 (PLP1) is a critical transmembrane protein and the major structural component of myelin sheaths in the central nervous system (CNS). It facilitates compaction, stabilization, and maintenance of myelin. Mutations or deletions in PLP1 are linked to neurological disorders like Pelizaeus–Merzbacher disease and Spastic paraplegia type 2.
- Other names
- DM20
02
Mechanism of action
PLP1 molecules bind to each other on adjacent membrane layers to tightly hold cellular membranes together for proper nerve insulation and rapid impulse conduction.
03
Biological functions
Myelin formationMyelin maintenanceOligodendrocyte developmentAxonal survivalIntestinal motility regulationBarrier function regulation
04
Disease associations
Pelizaeus–Merzbacher diseaseSpastic paraplegia type 2Leukodystrophy
05
Safety considerations
Gene duplications leading to overexpression.Missense mutations causing misfolded proteins.
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