Target intelligence / Profile preview

Proteolytic Enzymes in Aqueous Humor

Molecular classification: Enzyme, Protease, Serine protease, Elastase, Matrix metalloproteinase (MMP)

Overview

Proteolytic enzymes, or proteases, in the aqueous humor play roles in tissue remodeling, immune defense, and response to injury. Key types include serine proteases, elastase, and likely matrix metalloproteinases. These enzymes contribute to normal turnover of extracellular matrix, immune surveillance, and wound healing. Their activity is regulated by antiproteases like alpha 1-antitrypsin, alpha 2-macroglobulin, and serpins (e.g., SERPINA3). Dysregulation, with increased levels/activity, is linked to ocular surface burns, corneal ulcers, and glaucoma.

Biological functions

Protein degradationExtracellular matrix turnoverImmune defenseWound healing

Disease associations

Ocular surface burnsCorneal ulcersGlaucomaInflammation

Safety considerations

Uncontrolled proteolysis can damage ocular tissuesPotential for corneal ulceration and perforation

Beyond the preview

Go deeper on Proteolytic Enzymes in Aqueous Humor.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Proteolytic Enzymes in Aqueous Humor.

Explore the full profile