Proteome-wide Endogenous Proteins

Proteome-wide Endogenous Proteins refers to the entire set of proteins expressed by a genome, cell, tissue, or organism at a given time (UniProt). This term does not represent a single therapeutic target but rather the collective biological landscape that encompasses all potential receptors, enzymes, and transporters within a system. In modern pharmacology, proteome-wide screening is utilized to map the global interactome of small molecules, allowing for the identification of both primary therapeutic targets and unintended off-targets (Savitski et al., 2014, Science). Techniques such as Activity-Based Protein Profiling (ABPP) and Thermal Proteome Profiling (TPP) enable the study of these proteins in their native cellular environment, providing insights into drug selectivity and mechanism of action (Moellering & Cravatt, 2012, Molecular BioSystems). Understanding the proteome-wide impact of a drug is essential for predicting systemic toxicity and optimizing therapeutic efficacy across various disease states, including cancer and neurodegenerative disorders (Haura, 2014, JNCI).

Other names

ProteomeEndogenous proteomeCellular proteomeTotal protein complement

Not applicable as this refers to the entire set of proteins in a system rather than a single target.