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Target intelligence / Profile preview
Proteus species (Proteus spp.)
- Target
- Proteus spp.
- Molecular classification
- Bacteria, Gram-negative bacteria, Enterobacteriaceae
01
Overview
Proteus species are Gram-negative, rod-shaped bacteria known for their swarming motility and role as opportunistic pathogens. Key characteristics include urease production, H₂S production, and lactose-negative status on MacConkey agar. They are commonly found in the environment and as part of the intestinal flora. Pathogenicity is mainly associated with UTIs, wound infections, and septicemia. Virulence factors include urease, which leads to kidney stone formation, and swarming motility, which aids in colonization. Notable species include *Proteus mirabilis* and *Proteus vulgaris*.
- Other names
- Proteus mirabilisProteus vulgaris
02
Mechanism of action
Antibiotics target bacterial cell wall synthesis, DNA replication, or protein synthesis; urease inhibitors (hypothetical) block urease activity
03
Biological functions
MotilityUrease productionHydrogen sulfide productionBiofilm formationColonizationNutrient acquisitionDecomposition of organic matter
04
Disease associations
Urinary tract infections (UTIs)Wound infectionsSepticemiaCatheter-associated UTIsNosocomial infectionsKidney stone formation
05
Safety considerations
Antibiotic resistanceUrease production leading to alkaline urine and kidney stonesSwarming motility facilitating spread and colonizationBiofilm formation on catheters and other medical devices
06
Interacting drugs
Antibiotics (e.g., cephalosporins)
1 more in the full profile.
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