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Prothrombin Complex Protein
- Molecular classification
- Blood Coagulation Factors, Vitamin K-dependent proteins, Plasma-derived concentrate
01
Overview
Prothrombin complex protein (PCC) is a therapeutic preparation containing a combination of vitamin K-dependent blood coagulation factors, typically including factors II (prothrombin), VII, IX, and X, as well as proteins C and S. PCC is used primarily to reverse the effects of anticoagulant medications such as warfarin in patients experiencing acute major bleeding or requiring urgent surgery. It works by replenishing deficient clotting factors in the blood.
- Other names
- PCCKcentraBeriplexOctaplex
02
Mechanism of action
Replenishes deficient clotting factors, restoring the ability to form clots and control bleeding. Reverses elevated INR caused by vitamin K antagonists.
03
Biological functions
HemostasisBlood coagulationVitamin K metabolism
04
Disease associations
HemorrhageCoagulopathyVitamin K deficiencyFactor deficiency
05
Safety considerations
ThrombosisAnaphylaxisHepatitis transmission (plasma-derived products)Heparin-induced thrombocytopenia (if product contains heparin)
06
Interacting drugs
Warfarin
1 more in the full profile.
07
Biomarkers
INR (International Normalized Ratio)Levels of Factors II, VII, IX, XProtein C and S levels
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