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Target intelligence / Profile preview
Prothymosin alpha pseudogene 12 (PTMAP12)
- Target
- PTMAP12
- Molecular classification
- Pseudogene, Non-coding RNA, Other
01
Overview
Prothymosin alpha pseudogene 12 (PTMAP12) is a human processed pseudogene derived from the protein-coding prothymosin alpha (PTMA) gene, localized on chromosome 9. Unlike its parental gene, PTMAP12 is not believed to encode a functional protein. However, expression of PTMAP12 has been observed in some cancers, and recent transcriptomic analysis has identified PTMAP12 as a novel pseudogene with elevated expression in acute myeloid leukemia compared to chronic myeloid leukemia, but not in healthy individuals. Its function remains unclear, but as with other pseudogenes, PTMAP12 may potentially regulate gene expression or participate in oncogenic biology in cancer cells[1][3][4][5].
- Other names
- prothymosin α pseudogene 12PTMA pseudogene 12
02
Biological functions
Possible regulation of gene expressionPotential roles in cancer transcriptomeOther
03
Disease associations
CancerHematological malignancies (acute myeloid leukemia, chronic myeloid leukemia)Other
04
Biomarkers
Possible candidate biomarker for acute myeloid leukemia (AML) and chronic myeloid leukemia (CML)
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