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Target intelligence / Profile preview
Proto-oncogene c-Fos Protein (c-Fos)
- Target
- c-Fos
- Molecular classification
- Transcription factor, Proto-oncogene
01
Overview
Proto-oncogene c-Fos protein is a nuclear transcription factor critical for rapid cellular responses to external stimuli through regulation of gene expression. Its ability to form part of the AP‑1 complex underlies roles ranging from normal development/regeneration to cancer progression when dysregulated.
- Other names
- FOSAP-1 transcription factor subunit c-Fosp62 c-fos
02
Mechanism of action
Inhibition of AP-1 activity or c-Fos expression; modulation of upstream signaling pathways (e.g., MAPK)
03
Biological functions
Cell proliferationDifferentiationSurvivalAngiogenesisResponse to hypoxiaTissue regenerationGene expression regulationSignal transduction
04
Disease associations
CancerOsteoporosisDevelopmental defectsBehavioral abnormalities
05
Safety considerations
Potential for off-target effects due to widespread expression and involvement in multiple cellular processesDysregulation can promote tumorigenesis
06
Biomarkers
c-Fos expression levels as a prognostic marker in certain cancers
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