Myc proto-oncogene protein (c-Myc (or MYC))

Myc proto-oncogene protein (commonly called c-Myc or MYC) is a basic helix-loop-helix leucine zipper transcription factor encoded by the MYC gene. It is a key regulator of cell growth, proliferation, and metabolism, and controls expression of a wide array of genes by binding specific DNA sequences. As a proto-oncogene, MYC is frequently dysregulated in cancer, where its constitutive expression promotes uncontrolled cellular proliferation and tumorigenesis. Because of its central role in cancer, MYC is a highly studied but challenging therapeutic target, with most drug strategies focused on indirect inhibition via mRNA targeting or protein-protein interaction disruption[1][5].

Other names

c-MycMYCbHLHe39proto-oncogene c-Mycavian myelocytomatosis viral oncogene homolog

Inhibitors attempt to block MYC expression, promote MYC degradation, disrupt protein-protein interactions, or block translation of MYC mRNA[1]