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Target intelligence / Profile preview
Proto-oncogene c-Rel (c-Rel)
- Target
- c-Rel
- Molecular classification
- Transcription factor, NF-κB family member, Proto-oncogene
01
Overview
Proto-oncogene c-Rel is a transcription factor and member of the NF-κB family that plays a critical role in the immune system, particularly in lymphocyte function. It regulates various cellular processes including survival, proliferation, and immune responses. Dysregulation of c-Rel is associated with cancer, autoimmune diseases, and immunodeficiency, making it a potential therapeutic target.
- Other names
- RELv-Rel avian reticuloendotheliosis viral oncogene homolog
02
Mechanism of action
Modulation of c-Rel activity to influence gene expression and cellular function
03
Biological functions
Transcriptional regulationB-cell survivalB-cell proliferationAntibody productionLymphopoiesisImmune responseInflammatory responseDNA bindingDimerization
04
Disease associations
CancerB-cell lymphomasDiffuse large B-cell lymphomaHodgkin's lymphomaAutoimmune diseasesImmunodeficiencyInflammation
05
Safety considerations
Potential for broad immune modulation leading to unintended consequencesRisk of affecting multiple NF-κB target genesPossible disruption of immune homeostasis
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