Proto-oncogene DBL (MCF2)

Proto-oncogene DBL (MCF2) encodes a guanine nucleotide exchange factor (GEF) for the Rho family of small GTPases, primarily RhoA, Rac1, and Cdc42[1][2][3][8][9]. DBL functions by catalyzing the exchange of GDP for GTP, thereby activating downstream signaling pathways that regulate cytoskeleton dynamics, cell migration, cell adhesion, neurite extension, and synaptic development[2][8][9]. Alternative splicing generates multiple isoforms with distinct substrate specificities and tissue distributions[2][9]. Aberrant expression or mutation of MCF2 is associated with oncogenic transformation and progression in cancers (notably diffuse B-cell lymphoma), as well as roles in neurodevelopmental disorders and drug resistance[1][2][3][9][10]. MCF2 is part of the RhoGEF family and its activity is context-dependent, affecting developmental signaling and pathological processes.

Other names

DBLARHGEF21MCF2-transforming proteinDBL-transforming proteinMCF.2 cell line derived transforming sequenceProto-oncogene MCF-2Oncogene MCF2 (oncogene DBL)

Not applicable for direct therapeutic drugs. Drugs modulating Rho GTPase pathways typically act by influencing upstream GEFs like MCF2, interrupting exchange factor activity and preventing GTPase activation[2][3][8][9].