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Proto-oncogene Mas (MAS receptor)

Target: MAS receptor
Molecular classification: G protein-coupled receptor

Overview

MAS1 proto-oncogene (Mas receptor) is a G protein-coupled receptor (GPCR) that acts as a functional antagonist to the angiotensin II type 1 receptor (AGTR1). When activated by angiotensin-(1–7), it opposes many effects mediated by AGTR1, such as vasoconstriction and cell proliferation, leading to vasodilation, anti-inflammatory effects and other protective actions.

Other names: MASMGRAMRGA

Mechanism of action

Agonist binding leads to vasodilation, anti-inflammatory effects, anti-fibrotic effects, and metabolic regulation through antagonism of AGTR1 signaling.

Biological functions

VasodilationAnti-inflammatoryAnti-fibroticMetabolic regulationSignal transductionBlood pressure regulationMyocardial remodeling inhibitionGlucose homeostasis regulationAnti-proliferative actionAnti-metastatic action

Disease associations

HypertensionChronic kidney diseaseCongestive heart failureDilated cardiomyopathyPrimary biliary cholangitisCancerDiabetes mellitusChronic inflammatory diseases

Safety considerations

Limited availability of native-level detection antibodiesPotential for off-target effects due to related MAS-related G-protein coupled receptors

Interacting drugs

Angiotensin-(1–7)

2 more in the full profile.

Biomarkers

Chronic kidney diseaseCongestive heart failureDilated cardiomyopathyPrimary biliary cholangitis

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