Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Proto-oncogene Mas Receptor (Mas Receptor)
- Target
- Mas Receptor
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor, Class A GPCR
01
Overview
The MAS1 proto-oncogene receptor, also known as the Mas receptor, is a G protein-coupled receptor (GPCR) that functions as a key component of the renin–angiotensin system. It is activated by angiotensin-(1–7) and mediates vasodilation, cardioprotection, and anti-proliferative effects. While originally identified for its oncogenic potential, it can also act as an inhibitory regulator in certain cancers. It's a therapeutic target being explored for cardiovascular diseases, cancer, and diabetes.
- Other names
- MAS1MASMGRAMRGAMasR
02
Mechanism of action
Agonist binding stimulates phospholipase C signaling, activates RHO family GTPases (RHO, RAS, RAC), triggers ERK/MAPK and PI3K/AKT/mTOR pathways, and downregulates NFκB signaling.
03
Biological functions
VasodilationCardioprotectionAnti-proliferationSmooth muscle relaxationRegulation of blood pressureSignal transductionAngiogenesisGlucose homeostasisModulation of AGTR1 activityACE2-Ang-(1–7)-Mas axis effector
04
Disease associations
Cardiovascular diseaseCancerDiabetesMyocardial remodeling
05
Safety considerations
Potential oncogenic effects when dysregulated due to modulation of growth-regulating pathways.
06
Interacting drugs
Angiotensin-(1–7)
2 more in the full profile.
Beyond the preview
Go deeper on Proto-oncogene Mas Receptor (Mas Receptor).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Proto-oncogene Mas Receptor (Mas Receptor).