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Target intelligence / Profile preview
Proto-oncogene protein B-Raf (BRAF)
- Target
- BRAF
- Molecular classification
- Enzyme, Protein Kinase, Serine/threonine kinase
01
Overview
BRAF is a serine/threonine protein kinase that functions as a key component of the RAF family and regulates the MAP kinase/ERK signaling pathway. It plays a crucial role in cell division, differentiation, migration, secretion, and apoptosis. Mutations in BRAF, particularly V600E, are implicated in various cancers and developmental syndromes, making it an important therapeutic target. Inhibitors like vemurafenib and dabrafenib are used in treating late-stage melanoma with V600E mutations.
- Other names
- Serine/threonine-protein kinase B-Rafv-Raf murine sarcoma viral oncogene homolog B
02
Mechanism of action
Inhibition of BRAF kinase activity, specifically mutant forms like V600E
03
Biological functions
Signal transductionCell proliferationCell differentiationCell migrationSecretionApoptosisRegulation of MAP kinase/ERK signaling pathway
04
Disease associations
CancerRASopathiesMelanomaNon-Hodgkin lymphomaColorectal cancerThyroid carcinomaNon-small cell lung carcinoma (NSCLC)Hairy cell leukemiaNoonan syndrome (NS)Cardio-facio-cutaneous syndrome (CFC)Costello syndrome
05
Safety considerations
Resistance to BRAF inhibitors can developParadoxical activation of MAPK pathway in wild-type BRAF cellsNot effective against all BRAF mutation types
06
Interacting drugs
Vemurafenib
1 more in the full profile.
07
Biomarkers
BRAF V600E mutation (for patient selection in melanoma and other cancers)
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