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Target intelligence / Profile preview
Proto-oncogene protein c‑akt (AKT)
- Target
- AKT
- Molecular classification
- Serine/threonine kinase, Enzyme
01
Overview
Proto-oncogene protein c‑akt (AKT), also known as Protein Kinase B (PKB), is a serine/threonine kinase that plays a central role in multiple cellular processes, including cell survival, growth, proliferation, metabolism, and angiogenesis. Dysregulation or hyperactivation of AKT is implicated in various diseases, including cancer and type 2 diabetes.
- Other names
- Protein Kinase B (PKB)PKB-alpha (AKT1)PKB-beta (AKT2)PKB-gamma (AKT3)
02
Mechanism of action
Akt inhibitors block the kinase activity of AKT, preventing phosphorylation of downstream targets and inhibiting AKT-mediated cellular processes.
03
Biological functions
Cell survivalApoptosis regulationCell growthCell proliferationMetabolism regulationAngiogenesis regulationCell cycle progressionLysosomal biogenesis regulationAutophagy regulationSignal transduction
04
Disease associations
CancerType 2 DiabetesOvergrowth syndromes
05
Safety considerations
Dysregulation or hyperactivation can lead to tumorigenesisInhibition may have metabolic side effects
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