Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Proto-oncogene Protein c-AKT (AKT)
- Target
- AKT
- Molecular classification
- Enzyme, Serine/threonine kinase, Proto-oncogene
01
Overview
Proto-oncogene protein c-AKT, commonly referred to as AKT or Protein Kinase B (PKB), is a serine/threonine kinase that plays a central role in multiple cellular processes, including metabolism, cell proliferation, survival, growth, and angiogenesis. It is a key node in the PI3K/AKT signaling pathway and is highly conserved across higher eukaryotes. Dysregulation or hyperactivation of Akt signaling is implicated in various diseases, including cancer and diabetes.
- Other names
- Protein Kinase BPKBAKT1AKT2AKT3PKB-alphaPKB-betaPKB-gamma
02
Mechanism of action
AKT inhibitors
03
Biological functions
Cell survivalCell cycle progressionMetabolismLysosomal biogenesisAngiogenesisCell proliferationCell growth
04
Disease associations
CancerDiabetes Mellitus Type II
05
Safety considerations
Resistance mechanismsOff-target effects
Beyond the preview
Go deeper on Proto-oncogene Protein c-AKT (AKT).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Proto-oncogene Protein c-AKT (AKT).