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Target intelligence / Profile preview
Proto-oncogene protein c-hck (HCK)
- Target
- HCK
- Molecular classification
- Enzyme, Src family non-receptor cytoplasmic tyrosine kinase, Tyrosine-protein kinase
01
Overview
HCK (hematopoietic cell kinase) is a non-receptor tyrosine-protein kinase belonging to the Src family of kinases. It is primarily expressed in myeloid lineage cells and plays crucial roles in cell differentiation, leukocyte migration, and immune responses. Its involvement in various cancers and inflammatory diseases makes it a promising drug target.
- Other names
- Hematopoietic cell kinase
02
Mechanism of action
Kinase inhibition (potential)
03
Biological functions
Signal transductionCell differentiationLeukocyte migrationActin filament polymerization regulationFc-gamma receptor signalingRegulation of gene expressionRespiratory burst activationApoptosis
04
Disease associations
Hematologic malignanciesLeukemiaSolid tumorsBreast cancerColon cancerImmune dysregulationVasculitisPneumoniaInflammation
05
Safety considerations
Potential for immune suppressionOff-target effects on other kinases
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