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Target intelligence / Profile preview
Proto-oncogene protein c-KIT (c-KIT)
- Target
- c-KIT
- Molecular classification
- Receptor tyrosine kinase, Type III receptor tyrosine kinase, Transmembrane glycoprotein
01
Overview
Proto-oncogene protein c-KIT, also known as CD117, is a type III receptor tyrosine kinase that plays essential roles in cell signaling related to survival, proliferation, differentiation, and migration. It is activated by stem cell factor (SCF) and transduces signals through PI3K/AKT/mTOR, RAS/RAF/MEK/ERK MAPK, JAK/STAT, and PLCγ pathways. Dysregulation of c-KIT is implicated in various diseases, including GISTs, mastocytosis, and AML, making it a validated target for small molecule inhibitors like imatinib.
- Other names
- CD117Tyrosine-protein kinase KITMast/stem cell growth factor receptor (SCFR)
02
Mechanism of action
Inhibition of tyrosine kinase activity of c-KIT
03
Biological functions
Cell survivalCell proliferationCell differentiationCell migrationHematopoiesisMelanogenesisGametogenesisGastrointestinal motilitySignal transduction
04
Disease associations
CancerGastrointestinal stromal tumors (GISTs)MastocytosisAcute myeloid leukemia (AML)Piebaldism
05
Safety considerations
Resistance to tyrosine kinase inhibitorsOff-target effects of TKIs
06
Interacting drugs
1 more in the full profile.
07
Biomarkers
KIT mutational status (e.g., specific activating mutations in GISTs)
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