Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Proto-oncogene protein c-mas-1 receptor (MAS1)
- Target
- MAS1
- Molecular classification
- G protein-coupled receptor
01
Overview
The proto-oncogene protein c-mas-1 receptor, commonly referred to as MAS1, is a G protein-coupled receptor (GPCR) encoded by the MAS1 gene in humans. It is characterized by a seven-transmembrane domain structure typical of GPCRs and plays significant roles in cellular signaling pathways related to growth regulation, cardiovascular function, and inflammation. It acts primarily as a receptor for angiotensin-(1–7), a peptide hormone within the renin–angiotensin system (RAS). Upon activation by its ligand Ang-(1–7), the MAS1 receptor modulates several physiological processes including vasodilation, angiogenesis, antifibrotic and antihypertrophic effects.
- Other names
- MRGAMASMGRA
02
Mechanism of action
Agonist of MAS1 receptor leading to vasodilation, angiogenesis, and anti-inflammatory effects. Antagonists block these actions.
03
Biological functions
Signal transductionVasodilationAngiogenesisAnti-inflammationGrowth regulationCardiovascular function
04
Disease associations
Cardiovascular diseaseInflammationAtherosclerosisAutoimmune diseasesHypertension
05
Interacting drugs
Angiotensin-(1–7)
2 more in the full profile.
Beyond the preview
Go deeper on Proto-oncogene protein c-mas-1 receptor (MAS1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Proto-oncogene protein c-mas-1 receptor (MAS1).