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Target intelligence / Profile preview
Proto-oncogene protein c-mer (MERTK)
- Target
- MERTK
- Molecular classification
- Receptor tyrosine kinase, Transmembrane receptor, Enzyme, TAM receptor tyrosine kinase
01
Overview
Proto-oncogene protein c-mer (MERTK) is a receptor tyrosine kinase belonging to the TAM family. It plays a crucial role in cell survival, migration, differentiation, and the phagocytosis of apoptotic cells. MERTK is implicated in various cancers, where it contributes to angiogenesis, tumor cell migration and invasion, and enhanced cell survival signaling. Mutations in the MERTK gene are also linked to retinitis pigmentosa. As such, MERTK represents a promising therapeutic target, particularly in oncology drug development and cancer immunotherapy.
- Other names
- Mer tyrosine kinasec-merTyrosine-protein kinase MERMERTK proto-oncogene, receptor tyrosine kinase
02
Mechanism of action
Small molecule inhibitors selectively target c-MER/MERTK, inhibiting its kinase activity and downstream signaling pathways.
03
Biological functions
Cell survivalMigrationDifferentiationEfferocytosisImmune regulationTissue homeostasisPhagocytosis of apoptotic cells
04
Disease associations
CancerRetinitis pigmentosa
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