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Target intelligence / Profile preview
Proto-oncogene protein c-Met (MET)
- Target
- MET
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
MET, also known as the Hepatocyte Growth Factor Receptor (HGFR), is a receptor tyrosine kinase that plays a crucial role in cell proliferation, survival, morphogenesis, and motility. Upon activation by its ligand, Hepatocyte Growth Factor (HGF), MET initiates downstream signaling pathways, including PI3K-Akt, MAPK/ERK, and PLCγ, which are critical for both normal development and cancer progression. Aberrant activation of MET, through mutation, amplification, or overexpression, is implicated in various cancers, making it an important therapeutic target in oncology.
- Other names
- Hepatocyte Growth Factor Receptor (HGFR)c-MET
02
Mechanism of action
Inhibition of MET kinase activity, blocking downstream signaling pathways.
03
Biological functions
ProliferationSurvivalMorphogenesisMotilityMigrationInvasionTissue HomeostasisSignal Transduction
04
Disease associations
CancerTumorigenesisMetastasis
05
Safety considerations
On-target toxicities due to MET inhibition in normal tissuesDevelopment of resistance to MET inhibitorsOff-target effects of MET inhibitors
06
Biomarkers
MET overexpressionMET amplificationMET mutations
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