Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Proto-oncogene protein c-myc (MYC)
- Target
- MYC
- Molecular classification
- Transcription factor, bHLH-LZ family
01
Overview
MYC is a master regulator of cell growth, proliferation, metabolism, differentiation, apoptosis, and stem cell self-renewal. It is an intrinsically disordered nuclear protein that functions as a transcription factor, primarily through heterodimerization with MAX and binding to E-box DNA sequences. MYC is implicated in the majority of human tumors due to its central role in driving uncontrolled proliferation.
- Other names
- c-MycMYC proto-oncogene, bHLH transcription factorv-myc avian myelocytomatosis viral oncogene homolog
02
Mechanism of action
MYC overexpression or dysregulation leads to neoplastic transformation. Inhibition of MYC function is a therapeutic goal, but challenging.
03
Biological functions
Cell growthCell proliferationMetabolismDifferentiationApoptosisStem cell self-renewalTranscription regulation
04
Disease associations
Cancer
05
Safety considerations
MYC is a challenging therapeutic target due to its intrinsically disordered nature and lack of classical ligand-binding pockets suitable for small molecule inhibition.Inhibition of MYC may have pleiotropic effects due to its broad role in cell regulation, potentially leading to toxicity.
Beyond the preview
Go deeper on Proto-oncogene protein c-myc (MYC).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Proto-oncogene protein c-myc (MYC).