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Target intelligence / Profile preview
Proto-oncogene protein c-myc mRNA (c-Myc)
- Target
- c-Myc
- Molecular classification
- Transcription factor, Proto-oncogene
01
Overview
The proto-oncogene c-myc encodes a nuclear phosphoprotein, commonly referred to as c-Myc, which is a transcription factor with critical roles in cell cycle progression, apoptosis, cellular transformation, and metabolism. The *MYC* gene is located on human chromosome 8 and regulates the expression of approximately 15% of all genes by binding to enhancer box sequences (E-boxes) in DNA. Deregulation or overexpression leads to oncogenic transformation, frequently observed in many human cancers including lymphomas/leukemias. Constitutive activation disrupts normal control over proliferation/apoptosis/metabolism leading to tumorigenesis.
- Other names
- MYCv-myc avian myelocytomatosis viral oncogene homologc-myc mRNA
02
Mechanism of action
Dimerization with Max, binding E-boxes, recruitment of HATs/RNA pol II kinases, activation/repression of target genes
03
Biological functions
Cell cycleApoptosisCell proliferationMetabolismStem cell maintenanceTranscription regulation
04
Disease associations
CancerLymphomaLeukemiaTumorigenesis
05
Safety considerations
Oncogenic transformationConstitutive activation disrupting normal control over proliferation/apoptosis/metabolism
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