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Target intelligence / Profile preview
Proto-oncogene protein c-Rel (c-Rel)
- Target
- c-Rel
- Molecular classification
- Transcription factor, Proto-oncogene, NF-kappa-B transcription factor
01
Overview
Proto-oncogene protein c-Rel is a DNA-binding protein and a member of the NF-κB family of transcription factors. It plays a critical role in lymphocyte differentiation, especially B-cell survival and proliferation. As part of the NF-kappa-B complex, it regulates immune response, cell growth, apoptosis, and inflammation. The REL gene is amplified or mutated in several human B-cell lymphomas, contributing to tumorigenesis. c-Rel is considered a potential myeloid checkpoint protein and therapeutic target in hematologic malignancies.
- Other names
- RELV-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog
02
Mechanism of action
Inhibition of c-Rel transcriptional activity; disruption of NF-κB complex formation
03
Biological functions
Lymphocyte differentiationImmune response regulationCell growthApoptosisInflammationB-cell survivalB-cell proliferationRegulation of gene expression
04
Disease associations
CancerDiffuse large B-cell lymphomaHodgkin's lymphomaHematopoietic malignanciesB-cell lymphomas
05
Safety considerations
Potential for broad immunosuppression if targeted systemicallyOff-target effects on other NF-κB family membersRisk of promoting other malignancies if not targeted selectively
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