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Target intelligence / Profile preview
Proto-oncogene protein c-ret (RET)
- Target
- RET
- Molecular classification
- Receptor tyrosine kinase, Receptor
01
Overview
The RET proto-oncogene encodes a receptor tyrosine kinase crucial for neural crest development and maintenance. Upon ligand binding, RET dimerizes and activates intracellular signaling pathways regulating cell differentiation, growth, migration, and survival. RET is implicated in various diseases, including Hirschsprung's disease (loss-of-function) and multiple endocrine neoplasias and cancers (gain-of-function).
- Other names
- PTCMTC1HSCR1MEN2AMEN2BCDHF12CDHR16RET-ELE1
02
Mechanism of action
RET inhibitors block the tyrosine kinase activity of the RET receptor, preventing downstream signaling.
03
Biological functions
Cell differentiationGrowthMigrationSurvivalSignal transduction
04
Disease associations
Hirschsprung's diseaseMultiple endocrine neoplasia type IIa/b (MEN2A/MEN2B)Medullary thyroid carcinomaPapillary thyroid carcinomaPheochromocytomaParathyroid hyperplasiaThyroid cancerLung cancerColorectal cancerBreast cancerSalivary gland cancer
05
Safety considerations
Resistance to targeted therapies can develop due to mutations.Specific mutations may influence prognosis and treatment strategies.
06
Biomarkers
RET mutations (e.g., M918T)RET fusion genes (e.g., RET/PTC)
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