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Target intelligence / Profile preview
Proto-oncogene protein K-Ras (K-Ras)
- Target
- K-Ras
- Molecular classification
- Small GTPase, Proto-oncogene
01
Overview
Proto-oncogene protein K-Ras is a small GTPase that acts as a molecular switch in cellular signal transduction pathways, regulating cell proliferation, differentiation, and survival. Activating mutations in KRAS, particularly at codons 12 or 13, are common in human cancers, leading to constitutive activation of downstream signaling and tumorigenesis. Recent drug development efforts have focused on targeting specific mutant forms like KRAS^G12C^.
- Other names
- KRASKirsten rat sarcoma viral oncogene homologc-K-ras2
02
Mechanism of action
Inhibition of mutant K-Ras protein (e.g., KRAS^G12C^) to prevent activation of downstream signaling pathways.
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalRegulation of cell growthRegulation of cell division
04
Disease associations
Cancer
05
Safety considerations
Acquired resistanceOff-target effectsSpecificity for mutant isoforms
06
Interacting drugs
Sotorasib
3 more in the full profile.
07
Biomarkers
KRAS mutation status (e.g., G12C, G12D, G13D)
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