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Target intelligence / Profile preview
Proto-oncogene protein MDM2 (MDM2)
- Target
- MDM2
- Molecular classification
- E3 ubiquitin ligase, Proto-oncogene
01
Overview
MDM2 is a nuclear-localized E3 ubiquitin-protein ligase that negatively regulates the tumor suppressor protein p53. It binds to p53, inhibiting its transcriptional activity and promoting its degradation. Overexpression or amplification of MDM2 is observed in various cancers, leading to reduced p53 function and uncontrolled cell proliferation. MDM2 also participates in DNA repair pathways independently of its E3 ligase activity.
- Other names
- p53-binding proteinRING-type E3 ubiquitin transferaseOncoprotein Mdm2
02
Mechanism of action
Inhibition of MDM2-p53 interaction, leading to p53 activation and subsequent cell cycle arrest or apoptosis.
03
Biological functions
Negative regulation of p53Protein ubiquitinationCell cycle regulationApoptosis regulationDNA repair
04
Disease associations
CancerAccelerated tumor formationDedifferentiated liposarcoma
05
Safety considerations
Potential for off-target effects due to broad interactionsDevelopment of resistance through alternative pathwaysToxicity associated with p53 activation in normal tissues
06
Biomarkers
MDM2 overexpressionMDM2 amplification
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