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Target intelligence / Profile preview
Proto-oncogene protein N-Ras (N-Ras)
- Target
- N-Ras
- Molecular classification
- Small GTPase, Proto-oncogene
01
Overview
N-Ras is a small GTPase that acts as a molecular switch in signal transduction pathways regulating cell division, differentiation, and apoptosis. Mutations can lead to constitutive activation of the protein, driving uncontrolled cell proliferation, particularly in melanoma and hematologic malignancies. It is a proto-oncogene. While direct targeting is difficult, downstream effectors are therapeutic targets.
- Other names
- ALPS4CMNSN-rasNCMSNRAS1NS6Neuroblastoma RAS viral oncogene homolog
02
Mechanism of action
Inhibition of downstream effectors (e.g., RAF kinases)
03
Biological functions
Signal transductionCell proliferationCell differentiationApoptosisRegulation of cell division
04
Disease associations
Cancer
05
Safety considerations
Direct targeting of Ras is challenging due to its structureConstitutive activation drives uncontrolled cell proliferation
06
Interacting drugs
Sorafenib
07
Biomarkers
NRAS mutations (codons 12, 13, 61)
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