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Target intelligence / Profile preview
Proto-oncogene tyrosine-protein kinase Fyn (FYN)
- Target
- FYN
- Molecular classification
- Protein tyrosine kinase, Src family kinase, Enzyme
01
Overview
Proto-oncogene tyrosine-protein kinase Fyn (Fyn) is a non-receptor tyrosine kinase belonging to the Src family. It plays crucial roles in cell growth, survival, adhesion, cytoskeletal organization, and signal transduction pathways, particularly in immune cells and neurons. Fyn dysregulation is implicated in various diseases, including cancer and neurological disorders, making it a potential therapeutic target.
- Other names
- p59-FYNSLKSYNSrc Kinase p59MGC45350
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Regulation of cell growth and survivalCell adhesionCytoskeletal reorganizationSignal transductionImmune responseNeuronal developmentCell migrationSynaptic function
04
Disease associations
CancerImmunological disordersNeurodevelopmental disordersNeurodegenerationNeuroinflammation
05
Safety considerations
Potential for off-target effects due to kinase family conservationDysregulation can lead to oncogenic transformation
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