Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Proto-oncogene tyrosine-protein kinase Lyn (Lyn)
- Target
- Lyn
- Molecular classification
- Enzyme, Protein Kinase, Tyrosine Kinase, Non-receptor tyrosine kinase, Src family kinase
01
Overview
Lyn is a non-receptor tyrosine kinase belonging to the Src family. It plays a crucial role in various cellular processes, particularly in hematopoietic cells, by regulating signaling pathways involved in cell proliferation, survival, differentiation, migration, and immune responses. It acts as a rheostat modulating both activating and inhibitory signals, making it a key regulator of immune tolerance. Aberrant Lyn activity is implicated in various diseases, including autoimmune disorders and cancers.
02
Mechanism of action
Tyrosine kinase inhibition; destabilization of LYN protein
03
Biological functions
Signal transductionCell proliferationCell survivalCell differentiationCell migrationCell adhesionDegranulationCytokine releaseImmune responseRegulation of immune tolerance
04
Disease associations
Autoinflammatory diseaseVasculitisSarcomaLeukemiaLymphomaCancerAutoimmunity
05
Safety considerations
Potential for off-target effects due to broad expression and involvement in multiple signaling pathways
06
Interacting drugs
HSP90 inhibitors (indirectly via destabilization)
Beyond the preview
Go deeper on Proto-oncogene tyrosine-protein kinase Lyn (Lyn).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Proto-oncogene tyrosine-protein kinase Lyn (Lyn).