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Target intelligence / Profile preview
Proto-oncogene Tyrosine-Protein Kinase RET (RET)
- Target
- RET
- Molecular classification
- Receptor tyrosine kinase, Receptor
01
Overview
The RET protein is a receptor tyrosine kinase that plays a crucial role in cell signaling pathways regulating cell proliferation, migration, differentiation, survival, and maturation. It is essential for the normal development of the enteric nervous system, autonomic nervous system, and kidneys. RET acts as a cell-surface receptor for glial cell line-derived neurotrophic factor (GDNF) family ligands via GFRα coreceptors. Mutations in RET can lead to developmental disorders like Hirschsprung's disease (loss-of-function) or various cancers such as multiple endocrine neoplasia and papillary thyroid carcinoma (gain-of-function).
- Other names
- Rearranged during Transfection
02
Mechanism of action
RET kinase inhibition
03
Biological functions
Signal transductionCell proliferationCell migrationCell differentiationCell survivalCell maturationDevelopment of enteric nervous systemDevelopment of autonomic nervous systemKidney developmentSpermatogenesisBody weight regulation
04
Disease associations
Hirschsprung’s diseaseMultiple endocrine neoplasia type II A/BPapillary thyroid carcinomaPheochromocytomaParathyroid hyperplasiaNon-small cell lung cancerCancer
05
Safety considerations
On-target toxicities due to inhibition of RET signaling in normal tissuesResistance development
06
Biomarkers
RET mutations in tumorsRET fusion transcripts
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