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Target intelligence / Profile preview
Proto-oncogene Tyrosine-Protein Kinase ROS1 (ROS1)
- Target
- ROS1
- Molecular classification
- Receptor Tyrosine Kinase (RTK), Enzyme, Protein Kinase
01
Overview
The proto-oncogene tyrosine-protein kinase ROS1 is a receptor tyrosine kinase involved in epithelial cell differentiation and regionalization. Oncogenic fusions involving ROS1 are found in various cancers, particularly non-small cell lung cancer (NSCLC), where they drive tumorigenesis. Targeted therapies like repotrectinib have been developed to inhibit ROS1 kinase activity in cancers harboring ROS1 alterations.
- Other names
- ROS proto-oncogene 1, receptor tyrosine kinase
02
Mechanism of action
Inhibition of ROS1 kinase activity
03
Biological functions
Epithelial cell differentiationRegionalizationSignal transductionCell survivalCell growthCell proliferationCell differentiation
04
Disease associations
CancerNon-Small Cell Lung Cancer (NSCLC)
05
Safety considerations
Resistance to targeted therapiesOff-target effects of tyrosine kinase inhibitors
06
Interacting drugs
Repotrectinib
07
Biomarkers
ROS1 fusionsROS1-positive statusPhosphotyrosine expression
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