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Target intelligence / Profile preview
Proto-oncogene tyrosine-protein kinase Src (SRC)
- Target
- SRC
- Molecular classification
- Non-receptor tyrosine kinase, Enzyme
01
Overview
Proto-oncogene tyrosine-protein kinase Src (SRC) is a non-receptor tyrosine kinase that plays a central role in multiple cellular processes, including cell growth, development, and signal transduction. It is involved in pathways downstream of integrins and interacts with receptor tyrosine kinases, G-protein-coupled receptors, and steroid receptors. Aberrant SRC function is associated with cancer progression.
- Other names
- c-Srcp60src
02
Mechanism of action
Kinase inhibitor
03
Biological functions
Regulation of embryonic developmentCell growth regulationSignal transductionPhosphorylation of proteinsCell adhesionCell migrationCell proliferationCell differentiationCell survivalCell motilityAngiogenesisCytoskeletal organizationPre-mRNA processing
04
Disease associations
CancerColorectal CancerThrombocytopenia 6
05
Safety considerations
Potential for off-target effects due to the involvement of SRC in multiple cellular processes
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