Proto-oncogene tyrosine-protein kinase Src messenger RNA (SRC mRNA)

Proto-oncogene tyrosine-protein kinase Src (Src) mRNA is the transcript of the SRC gene, which encodes a non-receptor tyrosine kinase that serves as a central hub in cellular signaling pathways (NCBI Gene ID: 6714). The protein product, c-Src, is involved in regulating cell growth, survival, adhesion, and migration by interacting with a wide array of cell surface receptors and cytoplasmic proteins (UniProt P00533). Overexpression of Src mRNA is a common feature in various human cancers, including colorectal, breast, and lung carcinomas, where it contributes to tumor progression, epithelial-to-mesenchymal transition, and metastasis (PMID: 11406604). Therapeutic strategies targeting Src mRNA, such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), aim to reduce the overall expression of the Src protein, thereby inhibiting its oncogenic signaling (PMID: 9121473). This approach offers a potential advantage over small-molecule inhibitors by providing higher specificity and the ability to deplete the protein entirely rather than just inhibiting its catalytic activity (PMID: 17417627). While primarily in the preclinical and early clinical research stages, targeting Src mRNA remains a promising avenue for treating advanced and resistant malignancies (PMID: 24513176).

Other names

c-Src mRNASRC1 mRNApp60c-src mRNAProto-oncogene c-Src mRNAAvian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog mRNA

RNA interference (RNAi) or antisense-mediated degradation (RNase H) to reduce Src protein expression levels.