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Target intelligence / Profile preview
Protocadherin-10 (PCDH10)
- Target
- PCDH10
- Molecular classification
- Cell adhesion molecule, Cadherin superfamily member, Non-clustered protocadherin, δ2-protocadherin subfamily, Transmembrane protein, Receptor (neuronal receptor)
01
Overview
Protocadherin-10 is a calcium-dependent homophilic cell adhesion receptor, located on human chromosome 4q28.3, containing 6 extracellular cadherin repeats, a transmembrane domain, and a unique cytoplasmic tail. Predominantly expressed in the nervous system, PCDH10 plays key roles in brain development, neural circuit formation, regulation of cytoskeletal dynamics, and acts as a tumor suppressor in various cancers. Its loss or downregulation—commonly by promoter methylation—is associated with tumor progression and poor prognosis in several carcinomas, and may serve as a useful biomarker for early cancer detection.
- Other names
- OL-protocadherinOL-PCDHKIAA1400OLpcad
02
Mechanism of action
Restoration of PCDH10 expression (epigenetic therapy) to inhibit cancer cell proliferation, migration, and induce apoptosis Modulation of signaling pathways: inhibition of Wnt/β-catenin/BCL-9, NF-κB, AKT pathways
03
Biological functions
Cell-cell adhesionNeural circuit formation and maintenanceSynaptogenesisRegulation of actin assemblyCognitive functionTumor suppression
04
Disease associations
Cancer (tumor suppressor in gastric, colorectal, lung, and other cancers)Neurological disease (autism, cognitive disorder associations)
05
Safety considerations
No notable safety concerns directly attributed to PCDH10 modulation; therapeutic challenges relate to delivery, restoration of expression, and specificity in targeting methylation
06
Biomarkers
Aberrant methylation of the PCDH10 promoter as biomarker for cancer diagnosis/prognosis
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