Protocadherin beta-12 (PCDHB12)

Protocadherin beta-12 is a single-pass transmembrane protein and a member of the protocadherin beta gene cluster located on human chromosome 5. It contains six extracellular cadherin domains and a unique cytoplasmic tail that distinguishes it from other cadherins. Protocadherin beta-12 is most likely involved in calcium-dependent homophilic cell-cell adhesion in neural tissues, contributing to the specificity of synaptic connections necessary for neural circuit development and maintenance. The molecular organization and functional properties of the protocadherin clusters resemble those of immune receptors, but the precise physiological role of protocadherin beta-12 remains unclear, with no current evidence for therapeutic targeting. If you require further details about protein sequence, structure, or interactome, these entries can be found in UniProt (Q9Y5F1) or via genome databases.

Other names

Protocadherin beta-12PCDHB12PCDH-beta-12PCDH-BETA12protocadherin beta-12