Protocadherin beta-14 (PCDHB14)

Protocadherin beta-14 (PCDHB14) is a member of the protocadherin beta gene cluster, itself part of the broader cadherin superfamily of cell adhesion molecules[1][3][5]. It encodes a neural cadherin-like integral plasma membrane protein characterized by six extracellular cadherin domains and a unique cytoplasmic tail[3][5]. The beta cluster comprises 16 genes arranged in tandem on chromosome 5, each playing a probable role in specified neural cell-cell adhesion and connectivity[3][5]. Unlike the alpha and gamma protocadherin clusters, each protocadherin beta gene consists of a single large exon[3][5]. PCDHB14 demonstrates context-dependent functions: it acts as a tumor suppressor in hepatocellular carcinoma by promoting cell cycle arrest, inhibiting proliferation, and inducing ferroptosis, a form of regulated cell death[1][9]. Its expression is regulated by p53 and can be silenced by promoter hypermethylation in cancer, leading to tumor progression[1]. In neural development, PCDHB14 is thought to maintain synaptic specificity and function[1], and lower expression is linked to neurodevelopmental disturbances, including disorders like autism spectrum disorder and the impact of fetal alcohol exposure[5]. Despite its role in neural adhesion and tumor suppression, there are no well-characterized drugs that directly target PCDHB14, nor is it currently established as a therapeutic or diagnostic biomarker[5][9]. Note: No evidence supports its current use as a direct therapeutic target or the existence of interacting drugs or mechanisms of drug action. Its classification is predominantly as a structural and functional cell adhesion molecule, specifically within the nervous system[5].

Other names

Protocadherin beta-14PCDHB14PCDH-beta-14PCDH-BETA14PCDBE_HUMAN