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Target intelligence / Profile preview
Protocadherin beta-15 (PCDHB15)
- Target
- PCDHB15
- Molecular classification
- Cadherin superfamily, Clustered protocadherin beta subfamily, Cell adhesion protein, Plasma membrane protein
01
Overview
Protocadherin beta-15 is a cadherin superfamily cell adhesion protein encoded by the *PCDHB15* gene, found in the protocadherin beta cluster on chromosome 5. It has six extracellular cadherin domains and a cytoplasmic tail, and is expressed as a large single-exon transcript. Protocadherin beta-15 is thought to be important for the development and functioning of neural connections, though its precise biological roles are still being defined. Epigenetic silencing of *PCDHB15* by promoter methylation is implicated in breast cancer pathogenesis and proposed as a novel biomarker for breast cancer detection and prognosis.
- Other names
- Protocadherin beta-15PCDHB15PCDH-beta-15PCDH-BETA15protocadherin β15
02
Biological functions
Cell-cell adhesionCalcium ion bindingEstablishment and maintenance of specific neuronal connections
03
Disease associations
Cancer (e.g., breast cancer, as it may act as a tumor suppressor via promoter methylation and is a candidate epigenetic biomarker)Autism spectrum disorder (association reported)
04
Biomarkers
Methylation status of PCDHB15 promoter in circulating cell-free DNA as a minimally invasive biomarker for breast cancer diagnosis and prognosis
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