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Target intelligence / Profile preview
Protocadherin gamma-A10 (PCDHGA10)
- Target
- PCDHGA10
- Molecular classification
- Cell adhesion protein, Cadherin superfamily, Protocadherin gamma subfamily, Membrane protein, Other
01
Overview
Protocadherin gamma-A10 (PCDHGA10) is a member of the protocadherin gamma gene cluster within the cadherin superfamily of calcium-dependent cell adhesion molecules. It is primarily expressed in the brain and thought to play a critical role in establishing and maintaining specific neuronal connections. The gamma cluster contains multiple related genes organized in an immunoglobulin-like array, with each gene encoding a protein potentially involved in neural cell adhesion and signaling. Alterations in protocadherin genes, including PCDHGA10, have been linked to certain neurodevelopmental disorders, but this molecule is not a current therapeutic drug target and no drugs are known to interact with it[1][2][3][5].
- Other names
- Protocadherin gamma-A10PCDHGA10PCDH-gamma-A10Protocadherin gamma subfamily A, 10
02
Biological functions
Calcium-dependent cell adhesionEstablishment and maintenance of neuronal connectionsCell-cell adhesion, especially in neural tissueNeural development
03
Disease associations
Neurodevelopmental disorder with poor growth and skeletal anomaliesArboleda-Tham syndromePossible association with other neurodevelopmental and neurodegenerative diseases
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