Protocadherin gamma-C3 (PCDHGC3)

Protocadherin gamma-C3 (PCDHGC3) is a neural cadherin-like cell adhesion protein encoded by the PCDHGC3 gene, which is part of the protocadherin gamma gene cluster on chromosome 5[1][2]. This protein features six cadherin ectodomains, a transmembrane region, and a shared cytoplasmic region[1][2]. It is primarily expressed in the brain, where it plays a critical role in the establishment and function of specific neuronal connections and maintenance of blood-brain barrier integrity[2][3][4]. PCDHGC3 has been identified as an inhibitor of the Wnt/β-catenin signaling pathway, conferring tumor suppressor-like functions, particularly in colorectal cancer cells[3][4][5]. Loss of PCDHGC3 can increase endothelial proliferation and permeability, alter blood-brain barrier function, and dysregulate multiple intracellular signaling cascades[3][4]. While not routinely considered a primary therapeutic target or druggable receptor/enzyme, it is recognized for its essential roles in neural development and barrier homeostasis.

Other names

Protocadherin gamma subfamily C, 3PCDHGC3Protocadherin gamma-C3PCDH2PCDH-gamma-C3PC-43PC43Protocadherin-2Protocadherin-43cadherin-like 2

Inhibition of Wnt/β-catenin signaling (tumor suppression); Modulation of endothelial cell junction proteins (affecting barrier properties); Possible regulation of mTOR and MAP kinase signaling pathways