Protogenin (PRTG)

Protogenin (PRTG) is a single-pass transmembrane protein belonging to the immunoglobulin superfamily, specifically the DCC/neogenin subclass. Structurally, it contains four immunoglobulin-like domains, five fibronectin type III repeats, a signal peptide, and a cytoplasmic domain. During embryogenesis, PRTG is highly expressed in neural, craniofacial, and epithelial tissues where it regulates organ patterning and suppresses premature neuronal differentiation, preserving neural progenitor states. PRTG can dimerize and acts as a cell membrane receptor; its endogenous ligand is the secreted ERdj3 protein. Knockdown or inhibition of PRTG leads to increased neurogenesis and disrupted morphogenesis in multiple tissues. Although not implicated as a therapeutic target, PRTG has been linked genetically with neurodevelopmental conditions and is essential for correct vertebral and craniofacial patterning through modulation of TGFβ signaling and HOX gene activation[1][2][3].

Other names

ProtogeninPRTGIGDCC5Protein Shen-Danimmunoglobulin superfamily DCC subclass member 5FLJ25756shen-danprotogenin homolog (Gallus gallus)

Not established for any drugs. Experimentally, endogenous ligand is ERdj3, a stress-inducible protein that binds to PRTG and modulates neurogenesis through PRTG signaling[1].