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Proton Activated Chloride Channel 1

Molecular classification: Ion channel, Chloride channel, Proton-activated channel

Overview

PACC1 encodes a proton-activated chloride channel that is gated by extracellular acidic pH. Upon exposure to low pH, the channel facilitates the influx of chloride ions into cells. This activity is crucial for cellular responses to acidosis and can lead to cell swelling and acidosis-induced cell death.

Other names: C1orf75TMEM206

Mechanism of action

pH-gated chloride channel activity; mediates Cl⁻ influx upon extracellular acidification.

Biological functions

Chloride transportResponse to acidosisIon homeostasis

Disease associations

Lynch Syndrome 8Teeth Hard Tissue DiseaseHaverhill FeverCancerInflammation

Safety considerations

Acidosis-induced cell death due to increased chloride influx under acidic conditions

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