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Target intelligence / Profile preview
Proton-coupled Folate Transporter (PCFT)
- Target
- PCFT
- Molecular classification
- Transporter, Membrane Protein, Solute Carrier
01
Overview
The proton-coupled folate transporter (PCFT), encoded by the SLC46A1 gene, is a membrane protein responsible for the absorption of folates in the small intestine and delivery to the central nervous system. It functions as an electrogenic proton symporter, utilizing a proton gradient to transport folates into cells. PCFT is a target for developing antifolate chemotherapeutics that selectively enter cancer cells, which often have acidic microenvironments, to reduce toxicity.
- Other names
- SLC46A1G21HCP1solute carrier family 46 member 1
02
Mechanism of action
Facilitates the entry of antifolate chemotherapeutics into cells, particularly cancer cells, via proton-coupled transport.
03
Biological functions
Folate transportIntestinal absorptionCentral nervous system folate delivery
04
Disease associations
Hereditary Folate MalabsorptionCancer
05
Safety considerations
Potential for off-target toxicity if selectivity for tumor cells is not achievedDysfunction can lead to Hereditary Folate Malabsorption
06
Interacting drugs
Antifolates
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