Proton-transporting V-type ATPase complex assembly regulator TMEM9 (TMEM9)

Proton-transporting V-type ATPase complex assembly regulator TMEM9 (TMEM9) is a transmembrane protein involved in cellular processes such as intracellular pH regulation, lysosomal acidification, and protein degradation. TMEM9 facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), enabling vesicular acidification and trafficking. This function modulates canonical Wnt/β-catenin signaling (important for development, tissue homeostasis, regeneration, and tumorigenesis) by promoting lysosomal degradation of adenomatous polyposis coli protein (APC). TMEM9-regulated vesicle acidification also supports hepatic and mammary tissue regeneration, and plays roles in cancer and inflammatory cytokine secretion. TMEM9 is located in organelle membranes and mitotic structures; its protein sequence features a signal peptide, a transmembrane region, and glycosylation sites. No approved drugs directly target TMEM9, but pharmacological strategies acting on v-ATPases or downstream signaling could impact its functions (inference).

Other names

TMEM9TMEM9ADERP4DERM4Dermal papilla-derived protein 4HSPC186PSEC0012UNQ631/PRO1248Transmembrane protein 9Protein TMEM9

No specific mechanisms of action for drugs described in the search results; inhibition or modulation of v-ATPase or Wnt/mTOR pathways could be inferred as potential mechanisms (inference).